A major drug interaction exists between Lorazepam and Oxycodone. View detailed information regarding this drug interaction. In 2021, nearly 14% of overdose deaths involving opioids also involved benzodiazepines, a type of prescription sedative commonly prescribed for … Taking these medications together can put you at risk. Benzodiazepines are a type of sedative medication commonly prescribed to treat anxiety or … A major drug interaction exists between Lorazepam and Oxycodone. View detailed information regarding this drug interaction. Mixing opioids and benzodiazepines can be a dangerous combination. Here\’s what to know if you take both of these drugs. Hospice Care Queen Nancy explains the use of oxycodone and lorazepam—and other opioids and benzodiazepines used together—highlighting both … 2019 Concomitant use of benzodiazepines, including Lorazepam injection, and opioids may result in profound sedation, respiratory depression, coma, and death. If a … 2020